Periprosthetic Distal Femur Fractures: A Single-Center Retrospective Epidemiological Analysis
DOI:
https://doi.org/10.14744/ajh.86Keywords:
distal femur fracture, periprosthetic fracture, total knee arthroplasty, epidemiology, AO/OTA classification, Rorabeck classification, Vancouver classificationAbstract
Background and Aims: Distal femur fractures (DFFs) are relatively rare but clinically significant injuries associated with high morbidity and mortality. With the rising prevalence of total knee arthroplasty (TKA), the proportion of periprosthetic distal femur fractures (PPDFFs) has been increasing. The incidence, classification, and clinical characteristics of DFFs, with a particular focus on PPDFFs, were aimed to be evaluated in this study.
Methods: Patients admitted to our tertiary care trauma center between January 2020 and 2025 with a diagnosis of distal femur fracture were included in this retrospective descriptive study. Demographic data, mechanism of injury, fracture classification, treatment preference, surgical approach, recorded complications, and comorbidities were analyzed.
Results: A total of 56 patients were evaluated, including 46 (82.1%) with native DFFs and 10 (17.9%) with PPDFFs following TKA or Total hip arthroplasty (THA) . Female predominance was significantly higher in the PPDFF group compared to native fractures (100% vs. 63%, p=0.023). All PPDFFs resulted from simple falls (100%), whereas the native group had a more diverse trauma profile (p=0.036). Fracture type, Charlson Comorbidity Index and postoperative complication rates were similar between groups (p=0.702, p=0.170, p=0.639, respectively).
Conclusion: PPDFFs constituted 17.9% of all DFFs in our series, aligning with reports from tertiary referral centers. These injuries predominantly affect elderly women and are strongly associated with low-energy falls. The findings underscore the need for preventive strategies such as osteoporosis management and fall prevention, as well as for timely surgical intervention and updated epidemiological data to optimize treatment planning and improve outcomes.
References
Zlowodzki M, Bhandari M, Marek DJ, Cole PA, Kregor PJ. Operative treatment of acute distal femur fractures: systematic review of 2 comparative studies and 45 case series (1989 to 2005). J Orthop Trauma. 2006;20(5):366-71. doi:10.1097/00005131-200605000-00013. PMID:16766943.
Ehlinger M, Ducrot G, Adam P, Bonnomet F. Distal femur fractures. Surgical techniques and a review of the literature. Orthop Traumatol Surg Res. 2013;99(3):353-60. doi:10.1016/j.otsr.2012.10.014. PMID:23518071.
Beltran MJ, Gary JL, Collinge CA. Management of distal femur fractures with modern plates and nails: state of the art. J Orthop Trauma. 2015;29(4):165-72. doi:10.1097/BOT.0000000000000302. PMID:25793566.
Meinberg EG, Agel J, Roberts CS, Karam MD, Kellam JF. Fracture and Dislocation Classification Compendium—2018. J Orthop Trauma. 2018;32(S1):S1-S10. doi:10.1097/BOT.0000000000001063. PMID:29256945.
Ricci WM, Streubel PN, Morshed S, Collinge CA, Nork SE, Gardner MJ. Risk factors for failure of locked plate fixation of distal femur fractures: an analysis of 335 cases. J Orthop Trauma. 2014;28(2):83-9. doi:10.1097/BOT.0b013e31829e6dd0. PMID:23760176.
Liporace FA, Tang A, Jankowski JM, Yoon RS. Distal femur: nail plate combination and the linked construct. OTA Int. 2022;5(3):e172. doi:10.1097/OI9.0000000000000172. PMID:37781482; PMCID:PMC10538551.
Meek RM, Norwood T, Smith R, Brenkel IJ, Howie CR. The risk of peri-prosthetic fracture after primary and revision total hip and knee replacement. J Bone Joint Surg Br. 2011;93(1):96-101. doi:10.1302/0301-620X.93B1.25087. PMID:21196551.
Ülgen NK, Nazlıgül AS, Yiğit N, Erginoğlu SE, Akkurt MO. Epidemiologic Patterns of Musculoskeletal Disorders by Body Region Across 1.2 Million Orthopedic Visits: A 15-Year Experience From a Middle-Income Country. J Eval Clin Pract. 2025 Aug;31(5):e70230. doi: 10.1111/jep.70230. PMID: 40741843.
Rorabeck CH, Taylor JW. Periprosthetic fractures of the femur complicating total knee arthroplasty. Orthop Clin North Am. 1999;30(2):265-77. doi:10.1016/S0030-5898(05)70081-X. PMID:10196428.
Kim KI, Egol KA, Hozack WJ, Parvizi J. Periprosthetic fractures after total knee arthroplasties. Clin Orthop Relat Res. 2006;446:167-75. doi:10.1097/01.blo.0000214417.29335.19.
Pinaroli A, Piedade SR, Servien E, Neyret P. Intraoperative fractures and ligament tears during total knee arthroplasty. A 1795 posterostabilized TKA continuous series. Orthop Traumatol Surg Res. 2009;95(3):183-9. doi:10.1016/j.otsr.2008.04.002.
Martinet O, Cordey J, Harder Y, Maier A, Bühler M, Barraud GE. The epidemiology of fractures of the distal femur. Injury. 2000 Sep;31 Suppl 3:C62-3. doi: 10.1016/s0020-1383(00)80034-0.
Elsoe R, Ceccotti AA, Larsen P. Population-based epidemiology and incidence of distal femur fractures. Int Orthop.2018 Jan;42(1):191-196. doi: 10.1007/s00264-017-3665-1.
Miettinen S, Sund R, Törmä S, Kröger H. How Often Do Complications and Mortality Occur After Operatively Treated Periprosthetic Proximal and Distal Femoral Fractures? A Register-based Study. Clin Orthop Relat Res. 2023 Oct 1;481(10):1940-1949. doi: 10.1097/CORR.0000000000002638. Epub 2023 Apr 10.
Direder M, Naß C, Andresen JR, Dannenmann T, Bur F, Hajdu S, Haider T. Distal femoral fractures: periprosthetic fractures have four times more complications than non-periprosthetic fractures and cerclage should be avoided: retrospective analysis of 206 patients. J Orthop Traumatol. 2024 Sep 3;25(1):41. doi: 10.1186/s10195-024-00782-2.
Khan AM, Tang QO, Spicer D. The Epidemiology of Adult Distal Femoral Shaft Fractures in a Central London Major Trauma Centre Over Five Years. Open Orthop J. 2017 Nov 13;11:1277-1291. doi: 10.2174/1874325001711011277.
Holzer LA, Borotschnig L, Holzer G. Evaluation of FRAX in patients with periprosthetic fractures following primary total hip and knee arthroplasty. Sci Rep. 2023 May 2;13(1):7145. doi: 10.1038/s41598-023-34230-8. PMID: 37130875; PMCID: PMC10154289.
Park YB, Kim M, Nam HC, Jeon JW, Ha CW. Total knee arthroplasty and periprosthetic distal femoral fracture: looking beyond the osteoporosis to previous osteoporotic fracture. Osteoporos Int. 2024 Aug;35(8):1469-1475. doi: 10.1007/s00198-024-07138-w. PMID: 38801524.
Houel V, Marchasson G, Ramdane N, Philippoteaux C, Paccou J. Patients with periprosthetic femoral fractures are older adults who are commonly diagnosed with osteoporosis. Osteoporos Int. 2025 Jun;36(6):1061-1068. doi: 10.1007/s00198-025-07486-1. PMID: 40295337; PMCID: PMC12122641.
Mazur M, Beyer J, Elsamaloty M, Patel D, Liu J, Ebraheim NA. Surgical outcomes of periprosthetic distal femur fractures after total knee arthroplasty classified by Su et al. system. J Orthop. 2022 Sep 11;34:260-265. doi: 10.1016/j.jor.2022.09.005. PMID: 36148178; PMCID: PMC9486061.
Al-Jabri T, Ridha M, McCulloch RA, Jayadev C, Kayani B, Giannoudis PV. Periprosthetic distal femur fractures around total knee replacements: A comprehensive review. Injury. 2023 Apr;54(4):1030-1038. doi: 10.1016/j.injury.2023.02.037
Nauth A, Haller J, Augat P, Anderson DD, McKee MD, Shearer D, Jenkinson R, Pape HC. Distal femur fractures: basic science and international perspectives. OTA Int. 2024 Mar 11;7(2 Suppl):e320. doi: 10.1097/OI9.000000000000032015
Quinzi DA, Childs S, Lipof JS, Soin SP, Ricciardi BF. The Treatment of Periprosthetic Distal Femoral Fractures After Total Knee Replacement: A Critical Analysis Review. JBJS Rev. 2020 Sep;8(9):e2000003. doi: 10.2106/JBJS.RVW.20.00003
Nauth A, Ristevski B, Bégué T, Schemitsch EH. Periprosthetic distal femur fractures: current concepts. J Orthop Trauma. 2011 Jun;25 Suppl 2:S82-5. doi: 10.1097/BOT.0b013e31821b8a09. PMID: 21566481.
Shah JK, Szukics P, Gianakos AL, Liporace FA, Yoon RS. Equivalent union rates between intramedullary nail and locked plate fixation for distal femur periprosthetic fractures - a systematic review. Injury. 2020 Apr;51(4):1062-1068. doi: 10.1016/j.injury.2020.02.043. Epub 2020 Feb 16. PMID: 32115204.
Suh YM, Bardsley R, Hwang J, Sirois Z, Aneja A, Foster JA, Goetz JR, Kinchelow D, Sneed C, Dripchak S, Swart E, Garfi J, Askam B, Richard B, Jang Y, Poirier JL, Lopas L, Pean C, Dupree J, Bethell M, Kiwinda L, Brown M, Siegel J, Chen A. High rate of complications after operative fixation of open periprosthetic distal femur fractures. OTA Int. 2025 Apr 23;8(2):e400. doi: 10.1097/OI9.0000000000000400.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2025 Soner Sarı, Alperen Yiğit, Teoman Bekir Yeni, Yusuf İslam Üçtepe, Batuhan Gencer, Özgür Doğan

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.