Genital abscess, a complication of pelvic inflammatory disease (PID), mostly occurs in women of reproductive age and may become a life-threatening condition requiring emergent surgery. Genital abscesses rarely develop secondary to gastrointestinal tract infections. In our case, a sigmoid colon perforation was detected in a woman of reproductive age who underwent laparotomy with a preliminary diagnosis of tubo-ovarian abscess. The condition progressed to sepsis within hours, and the perforation developed secondary to colon malignancy. Tubo-ovarian abscesses in women of reproductive
age are usually easy to diagnose. However, gastrointestinal malignancies are rare at this age, so they are often not considered as diagnostic options and may be overlooked. Proper documentation of clinical differential diagnoses for managing complicated gynecological emergencies contributes positively to prognosis. Our case, which required a complex and multidisciplinary approach, is important as an example of rapid and effective management.