A Case Report: Pyoderma Gangrenosum, Acne and Hidradenitis Suppurativa (PASH) Syndrome

PASH syndrome, consisting of the triad of pyoderma gangrenosum (PG), acne, and hidradenitis suppurativa (HS), is a rare chronic autoinflammatory disease. The etiology and pathogenesis of the syndrome are not yet clearly understood. However, certain genes, such as PSTPIP1, have been associated with this syndrome. In treating PASH syndrome, various options are available depending on the disease’s severity, including recommendations for weight loss and smoking cessation. Furthermore, there is a rare possibility of cutaneous malignancy developing in HS, a component of PASH syndrome, which tends to worsen the prognosis for these patients. In HS patients, distinguishing between malignant transformation in chronic lesions and classical lesions is challenging, potentially leading to diagnostic delays. Therefore, in high-risk patients with long-standing atypical ulcerative lesions, malignancy should be suspected. This case report presents a 46-year-old male patient diagnosed with PASH syndrome.